Influence of antigen dose and DC number on CD8+ T cell differentiation and proliferation of OT-ⅰ transgenic mice 抗原浓度和DC数量对OT-I小鼠CD8~+T细胞分化与增殖的影响
Thus, Histoplasma-induced host cell apoptosis would be key to CD8 T cell activation in the infected host. 因此,组织胞浆菌所引起之宿主细胞的死亡对于感染后宿主体内CD8T细胞的活化是很重要的。
However, how CD8 T cell are activated in vivo remains unclear. 然而,体内之CD8T细胞是如何被活化的目前并不清楚。
OBJECTIVE: To investigate the effect of cyclosporine on CD8+ T cell to release soluble CD8 antigen ( SCD8). 目的:探讨环孢素对CD8~+T细胞释放可溶性CD8(SCD8)的影响。
Results The histological change of HE staining and Gomori Ag staining indicated the fibrogenesis in model group mice. Immunohistochemical staining for CD4+ or CD8+ T cell indicated that the infiltrating lymphocytes in liver parenchyma were mainly CD4+ T lymphocytes. 结果模型组小鼠苏木精伊红染色和Gomori染色提示实验中晚期发生肝纤维化,冰冻切片免疫组织化学染色提示肝组织内淋巴细胞浸润以CD4+细胞为主。
Further study found that CD8+ T cell memory relates strongly to the persistence of antigen. Thus the contribution of antigen to maintenance of T cell memory is reconfirmed. 通过进一步模拟发现CD8+T细胞记忆与抗原的存在紧密相关,再次证实了抗原在维持T细胞记忆中的作用。
The so called restrictive cytotoxicity of CTL results from MHC peptide complex specifically activates the corresponding CD8+ T cell clone. 所谓CTL的特异性杀伤作用,是MHC抗原肽复合物表面信息激活该信息特异性T细胞克隆的结果。
Objective To investigate the effect of CD86 ( B7-2) on the differentiation of CD8+ T cell in vitro. 目的探讨CD86(B72)对CD8+T细胞分化的影响。
There were no significant differences of the percentage of T lymphocyte subset and CD4+/ CD8+ T cell ratio between CTG and CG. CTG小鼠脾脏中各T细胞亚群的百分率及CD4+/CD8+T细胞的比例与CG组无显著差异。
[ Results] A CD4+ T cell clone named TWH PI-1 and a CD8+ T cell clone named TWH PI-2 specific to PI protein antigen were isolated. [结果]建立了PI抗原特异性的CD4~+T细胞克隆TWHPI-1,CD8~+T细胞克隆TWHPI-2。
Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C 人类急性丙型肝炎纵向研究中对CD8+T细胞反应的全面分析
Study on HIV-1 Nef Specific CD8+ T Cell Responses in Chinese Population 中国人群HIV-1Nef蛋白特异性CD8+T细胞应答反应的研究
The CM+/ CD8+ T cell ratio was tested by flow cytometry. 流式细胞术检测免疫鼠脾细胞中CD4+和CD8+T细胞的比率。
CD8+ T cell changed more obviously in mice immunized with CpG adjuvant vaccine. 而CpG佐剂疫苗免疫小鼠的CD8+T细胞百分比改变较其它佐剂疫苗改变更明显。
We Concluded that immunological function in neonatal HIE was impaired. The levels of CD3+, CD4+, CD8+ T cell and IL-6, IL-8 could be a marker for the disease severity assessing and outcome predicting. 结论:新生儿HIE免疫功能受损,CD3+、CD4+、CD8+细胞和IL-6、IL-8水平对临床早期判断病情严重性、估计预后、指导治疗有一定意义。
Objective To explore the changes of CD8+ T cell subtypes especially CD8+ CD28-T suppressor cells in rats with experimental colitis induced by 2,4-dinitrofluorobenzene ( DNFB). 目的探讨CD8+T细胞亚群尤其是CD8+CD28-T抑制细胞在2,4二硝基氟苯(DNFB)大鼠实验性结肠炎模型中的变化及其可能作用。
Objective: To map the susceptibility allele of aberrant peripheral CD8+ T cell number in SLE model-( NZB × NZW) F1 mice. 目的:定位自发性SLE模型(NZB×NZW)F1小鼠CD8+T细胞数量异常的遗传易感基因。
RESULTS: Serum IFN-γ level and the percentage of splenic T lymphocyte subset in IG were decreased significantly, CD4+/ CD8+ T cell ratio increased significantly as compared with those of CG. 结果与CG组相比较,IG小鼠血清IFN-γ的水平及脾脏中各T细胞亚群的百分率均降低;而CD4+/CD8+T细胞的比例升高。
Results The C3, C4 levels, complement activity and anti-pig endotheliocyte xenoantibody were decreased to some extent in the serum after hyperacute rejection, and the ratio of CD4+/ CD8+ T cell was also decreased. 结果发生超急性排斥反应时,血清补体C3、C4的含量、总补体活性及抗猪内皮细胞天然抗体均有一定程度的下降;CD4+/CD8+T淋巴细胞的比率也有所下降;
Peripheral blood T-cell subgroups ( CD3+, CD4+, CD8+ T cell), serum PRA, C-reactive protein and CK were detected in 20 persons in healthy control group; 健康对照组20人均采外周血检测外周血T细胞亚群(CD3+,CD4+,CD8+T细胞)、血清群体反应性抗体、C反应蛋白和肌酸肌酶;
Objective To explore whether CD4+/ CD8+ T cell ratios could be used as a mark in early diagnosing liver transplant rejection or not and whether rIL-2 could reverse CsA-induced tolerance or not. 目的探讨外周血中CD4+/CD8+T细胞比值对肝移植排斥反应的早期诊断价值以及rIL-2逆转CsA诱导的肝移植耐受作用。
Results IL 6 level was obviously increased in the infertile women with mild endometriosis compared with the controls. CD4+ T cell number in peripheral blood was increased while CD8+ T cell number had no evident changes. 结果与对照组相比,轻度子宫内膜异位症不孕患者腹腔液IL6水平显著增高,外周血CD4+T细胞数目增加,而CD8+T细胞变化不明显。
We have done experimental research on psoriatic patients by determining autonomous nervous system regulating function, the angiotensin ⅱ in blood plasma, and the CD3, CD4 and CD8 T cell in peripheral blood, both before and after biofeedback relax therapy. 我们进行了生物反馈治疗前后的自主神经调节功能、血管紧张素Ⅱ以及外周血CD3,CD4及CD8T细胞的基础实验研究;
The expressions of CD96 on CD4+ T cell, CD8+ T cell and NK cell were up-regulated after PHA stimulation, confirming that CD96 is an activation increased molecule. 在PHA刺激后,CD4+T细胞、CD8+T细胞和NK细胞上CD96表达明显上调,证实CD96是一种活化表达增加的分子。
OVA could lead the number of CD4+ T cell and CD8+ T cell to reduce, and could influence the number of intestinal flora. OVA能够导致小肠粘膜CD4+T细胞和CD8+T细胞数量减少,能够对肠道菌群产生一定影响。
It applies flow cytometry to detect expression of CD28 and CTLA-4 of peripheral and decidual lymphocytes in CD3+ CD4+ T and CD3+ CD8+ T cell. 采用流式细胞技术测定外周血及蜕膜淋巴细胞CD28和CTLA-4在CD3+CD4+T细胞和CD3+CD8+T细胞上的表达水平。